Principales publications scientifiques

Sélection d’hypothèses, articles originaux, et revues générales sur la mort cellulaire programmée publiées dans des revues scientifiques internationales à comité de lecture :

1. -Deschaumes C, Verneuil L, Ertault-Daneshpouy M, Adle-Biassette H, Galateau F, Aïnoun F, Micic-Polianski J, Janin A, Ameisen JC. CD95 ligand-dependant endothelial cell death initiates oral mucosa damage in a murine model of acute graft versus host disease. Lab Invest 2007, 87:417-29
   

2. -Lelievre JD, Petit F, Arnoult D, Ameisen JC, Estaquier J. Interleukin 7 increases human immunodeficiency virus type 1 LAI-mediated Fas-induced T-cell death. J Virol 2005, 79:3195-9
   

3. -Benveniste O, Flahault A, Rollot F, Elbim C, Estaquier J, Pedron B, Duval X, Dereuddre-Bosquet N, Clayette P, Sterkers G, Simon A, Ameisen JC, Leport C. Mechanisms involved in the low-level regeneration of CD4+ cells in HIV-1-infected patients receiving highly active antiretroviral therapy who have prolonged undetectable plasma viral loads. J Infect Dis 2005, 191:1670-9
   

4. -Pleskoff O, Casarosa P, Verneuil L, Ainoun F, Beisser P, Smit M, Leurs R, Schneider P, Michelson S, Ameisen JC. The human cytomegalovirus-encoded chemokine receptor US28 induces caspase-dependent apoptosis. FEBS J 2005, 272:4163-77
   

5. -Lelièvre JD, Mammano F, Arnoult D, Petit F, Grodet A, Estaquier J, Ameisen JC. A novel mechanism for HIV1-mediated bystander CD4+ T-cell death: neighboring dying cells drive the capacity of HIV1 to kill non-cycling primary CD4+ T cells. Cell Death Differ 2004, 11:1017-27
   

6. -Ameisen JC. Looking for death at the core of life in the light of evolution. (News and Commentary). Cell Death Differ 2004, 11:4-10
   

7. -Socie G, Mary JY, Lemann M, Daneshpouy M, Guardiola P, Meignin V, Ades L, Esperou H, Ribaud P, Devergie A, Gluckman E, Ameisen JC, Janin A. Prognostic value of apoptotic cells and infiltrating neutrophils in graft-versus-host disease of the gastrointestin tract in humans: TNF and Fas expression. Blood 2004, 103:50-7
   

8. -Zhao WL, Ertault Daneshpouy M, Mounier N, Briere J, Leboeuf C, Plassa LF, Turpin E, Cayuela JM, Ameisen JC, Gisselbrecht C, Janin A. Prognostic significance of Bcl-xL gene expression and apoptotic cell counts in follicular lymphoma. Blood 2004, 103:695-7
   

9. -Arnoult D, Petit F, Lelièvre JD, Lecossier D, Hance A, Monceaux V, Ho Tsong Fang R, Hurtrel B, Ameisen JC, Estaquier J. Caspase-dependent and -independent T-cell death pathways in pathogenic simian immunodeficiency virus infection: relationship to disease progression. Cell Death Differ 2003, 11:1240-52
   

10. -Monceaux V, Estaquier J, Février M, Cumont MC, Rivière Y, Aubertin AM, Ameisen JC, Hurtrel B. Extensive apoptosis in lymphoid organs during primary Simian Immunodeficiency Virus infection predicts rapid progression towards AIDS. AIDS 2003 17:1585-96
    

11. -Ameisen JC, Pleskoff O, Lelièvre JD, DeBels F. Subversion of cell survival and cell death: viruses as enemies, tools, teachers and allies. (News and Commentaries) Cell Death Differ 2003, 10 (sup. 1):3-6
    

12. -Ameisen JC, Lelièvre JD, Pleskoff O. HIV/host interactions: new lessons from the Red Queen's country. AIDS 2002, 16 (sup.4 2002 A year in review): S25-31
    Arnoult D, Parone P, Martinou JC, Antonsson B, Estaquier J, Ameisen JC. Mitochondrial release of Apoptosis Inducing Factor occurs downstream of cytochrome c release in response to several proapoptotic stimuli. J Cell Biol 2002, 159:923-9
    

13. -Janin A, Deschaumes C, Daneshpouy M, Estaquier J, Micic-Polianski J, Rajagopalan-Levasseur P, Akarid K, Mounier N, Gluckman E, Socié G, Ameisen JC. CD95 engagement induces disseminated endothelial-cell apoptosis in vivo: immunopathological implications. Blood 2002, 99:2940-47
    

14. -Ameisen JC. On the origin, evolution, and nature of programmed cell death: a timeline of four billion years. Cell Death Differ 2002, 9:367-93
    

15. -Arnoult D, Akarid K, Grodet A, Petit PX, Estaquier J, Ameisen JC. On the evolution of programmed cell death: apoptosis of the unicellular eukaryote Leishmania major involves cysteine proteinase activation and mitochondrion permeabilization. Cell Death Differ 2002, 9:65-81.
    

16. -Arnoult D, Tatischeff I, Estaquier J, Girard M, Sureau F, Tissier JP, Grodet A, Dellinger M, Traincard F, Kahn A, Ameisen JC, Petit PX. On the evolutionary conservation of the cell death pathway: mitochondrial release of an Apoptosis Inducing Factor during Dictyostelium discoideum cell death. Mol Biol Cell 2001, 12:3016-30
    

17. -Ameisen JC. Apoptosis subversion: HIV-Nef provides both armor and sword (News and Views) Nature Medicine 2001, 7:1181-2
    

18. -Bratosin D, Estaquier J, Petit F, Arnoult D, Quatannens B, Tissier JP, Slomianny C, Sartiaux C, Alonso C, Huart JJ, Montreuil J, Ameisen JC. Programmed cell death in mature erythrocytes: a model for investigating death effector pathways operating in the absence of mitochondria. Cell Death Differ 2001, 8:1143-56
    

19. -Estaquier J, Monceaux V, Cumont MC, Aubertin AM, Hurtrel B, Ameisen JC. Early changes in peripheral blood T cells during primary infection of rhesus macaques with a pathogenic SIV. J Med Primatol 2000, 29:127-35.
    

20. -Ameisen JC, "The evolutionary origin and role of programmed cell death in single celled organisms: a new view of executioners, mitochondria, host-pathogen interactions, and the role of death in the process of natural selection", in : When Cells die. R. Lockshin, Z. Zakeri, J. Tilly (éds.). New York, Wiley-Liss, Inc., 1998, pp. 3-56.
    

21. -Ameisen JC. HIV: Setting death in motion. (News and Views) Nature 1998, 395: 117-119.
    

22. -Quignon F, DeBels F, Koken M, Feunteun J, Ameisen JC, de Thé H. PML-induces a novel caspase-independent cell death process. Nature Genetics 1998, 20:259-64
    

23. -Estaquier J, Ameisen JC. A role for T helper type 1 and type 2 cytokines in the regulation of human monocyte apoptosis. Blood 1997, 90:1618-25.
    

24. -Ameisen JC. The origin of programmed cell death. (Perspective) Science 1996, 272:1278-9.
    

25. -Estaquier J, Tanaka M, Suda T, Nagata N, Golstein P, Ameisen JC. Fas-mediated apoptosis of CD4+ and CD8+ T cells from HIV-infected persons: differential in vitro preventive effect of cytokines and protease antagonists. Blood 1996, 87:4959-66
    

26. -Ameisen JC, Idziorek T, Billaut-Mulot O, Loyens M, Tissier JP, Potentier A, Ouaissi MA. Apoptosis in a unicellular eukaryote (Trypanosoma cruzi): implications for the evolutionary origin and role of programmed cell death in the control of cell proliferation, differentiation and survival. Cell Death and Differentiation 1995, 2:285-300
    

27. -Ameisen JC, Estaquier J, Idziorek T, De Bels F. The relevance of apoptosis to AIDS pathogenesis. Trends in Cell Biology 1995, 5:27-32.
    

28. -Estaquier J, Idziorek T, Zou W, Emilie D, Farber CM, Bourez JM, Ameisen JC. Th1/Th2 cytokines and T-cell death: preventive effect of IL-12 on activation-induced and CD95 (Fas/Apo-1)-mediated apoptosis of CD4+ T cells from HIV-infected persons. Journal of Experimental Medicine 1995, 182:1759-67.
    

29. -Ameisen JC. Programmed cell death (apoptosis) and cell survival regulation: relevance to AIDS and cancer. Editorial Review, AIDS 1994, 8:1197-1213.
    

30. -Ameisen JC, Estaquier J, Idziorek T. From AIDS to parasite infection: pathogen-mediated subversion of programmed cell death as a mechanism for immune dysregulation. Immunological Reviews 1994, 142:9-51.
    

31. -Estaquier J, Idziorek T, De Bels F, Barré-Sinoussi F, Hurtrel B, Aubertin AM, Venet A, Mehtali M, Muchmore E, Michel P, Mouton Y, Girard M, Ameisen JC. Programmed cell death and AIDS: the significance of T-cell apoptosis in pathogenic and non pathogenic primate models of lentiviral infection. Proceedings of the National Academy of Sciences USA 1994, 91:9431-5.
    

32. -Groux H, Monté D, Plouvier B, Capron A, Ameisen JC. CD3-mediated apoptosis of human medullary thymocytes and activated peripheral T cells: respective roles of IL-1, IL-2, IFN-g, and accessory cells. Eur J Immunol 1993, 23:1623-9.
    

33. -Groux H, Torpier G, Monté D, Mouton Y, Capron A, Ameisen JC. Activation-induced death by apoptosis in CD4+ T cells from HIV-infected asymptomatic individuals. J Exp Med 1992, 175:331-40.
    

34. -Ameisen JC. Programmed cell death and AIDS pathogenesis: from hypothesis to experiment. Immunology Today 1992, 13:388-91.
    

35. -Ameisen JC. The programmed cell death theory of AIDS pathogenesis: implications, testable predictions, and confrontation with experimental findings. Immunodeficiency Reviews 1992, 3:237-46
    

36. -Ameisen JC, Capron A. Cell dysfunction and depletion in AIDS: the programmed cell death hypothesis. Immunology Today 1991, 12:102-5 [hypothèse soumise en mai 1990, publiée en avril 91].
    

Brevets :
Le programme de recherches de JC Ameisen a donné lieu en 1991 au dépôt d'une demande de brevet portant sur la prévention de l'apoptose comme base d'une nouvelle stratégie thérapeutique :

1. -Ameisen JC, Groux H, Capron A, Ameisen F. Médicament contenant un agent inhibant in vivo l'apoptose pathologique et applications. Demande de brevet n° 91.03 739, 3/27/91 Demande Internationale n° PCT/FR 92/00 265, 3/23/92.
   

Deux brevets sur les applications thérapeutiques de la régulation de l’apoptose et des inhibiteurs de caspases ont été déposés en 1998 :

1. -Ameisen JC, Bratosin D, Estaquier J, Huart J, Montreuil J. 1998 (concernant les applications thérapeutiques de la régulation de l'apoptose par des inhibiteurs de caspases) ;
   

2. -Koken M, Quignon F, de Thé H, Ameisen JC, De Bels F. Utilisation de nouveaux agents inducteurs de mort cellulaire en synergie avec les interférons. Priorité France n° 98.09 886, demande internationale PCT/FR 99/01 901. Partenaire industriel pharmaceutique international (2001).
   

Un brevet sur une nouvelle stratégie du traitement du paludisme a été déposé en 2003 :

1. -Tomavo S, Dzierszinski F, Coppin A, De Bels F, Ameisen JC. Utilisation d'une nouvelle classe de médicaments pour le traitement de maladies parasitaires. Demande internationale PCT/FR03/00107, 2003
   

Principales conférences dans des congrès scientifiques internationaux (conférencier invité) sur la mort cellulaire programmée :

1. -“Activation-induced CD4+ T-cell death by apoptosis and AIDS pathogenesis”, VI Colloque des Cent Gardes (M. Girard, L. Valette; Pasteur Mérieux) Marnes la Coquette, France (1991)
   

2. -“Programmed cell death and AIDS pathogenesis”. New Concepts in AIDS pathogenesis, Les Pensières (L. Montagnier) (FERS, CEE, Fondation M. Mérieux), France (1992)
   

3. -“Programmed cell death and AIDS pathogenesis”, Rhone Poulenc-Rorer, Science Expo 92, Collegeville , PA, USA (1992)
   

4. -“Programmed cell death and AIDS pathogenesis” Ramon Areces Foundation, Division of Immunology: International Symposium Advances in pathogenesis and therapy of HIV infection and AIDS, Madrid, Espagne (1992)
   

5. -“The programmed cell death (apoptosis) theory of AIDS pathogenesis: confrontation with experimental findings”. Table ronde, présidée par N. Letvin: “Mechanisms involved in CD4+ T cell depletion”, VIII International Conference on AIDS, Amsterdam, Hollande (1992)
   

6. -“T-cell death by apoptosis in AIDS” 1993 ENII (European Network of Immunology Institutes) conference: “Integrated function of molecules of the immune system”, (P. Beverley) Les Embiez, France
   

7. -“Programmed cell death and AIDS pathogenesis” Primary HIV infection Workshop NIH, (M.T. Niu, S.M. Schnittman), Bethesda, USA (1993)
   

8. -“Programmed cell death and AIDS pathogenesis” Annual Meeting of the Canadian Society for Immunology, Symposium on “Cytotoxicity and apoptosis in the immune system” (A. Greenberg),Lake Louise, Alberta, Canada (1993)
   

9. -“Programmed cell death and AIDS pathogenesis” Keystone Symposium: Frontiers in HIV pathogenesis, Albuquerque, NM, USA (1993)
   

10. -“Programmed cell death and AIDS pathogenesis”, et Chairman de la session “Pathophysiology of AIDS” Laboratory of Tumor Cell Biology Annual Meeting(R.C. Gallo), Bethesda, MD, USA. (1993)
    

11. -“Programmed cell death (apoptosis) and AIDS pathogenesis: an update”, VIII Colloque des Cent Gardes (M. Girard, L. Valette) (1993)
    

12. -“Programmed cell death and AIDS pathogenesis”, Conference on oxidative stress in HIV/AIDS, Fogarty International Center; National Institutes of Health (H Greenspan), Bethesda, MD, USA (1993)
    

13. -“Apoptosis and AIDS”, French-Japonese Symposium on AIDS, Tokyo, National Institute of Health (1993)
    

14. -“Programmed cell death and AIDS pathogenesis”, Paris Conference on Apoptosis in AIDS and Cancer (L. Montagnier) (1993)
    

15. -“Programmed cell death and AIDS pathogenesis”. Table ronde présidée par A.S. Fauci: “Mechanisms of CD4 T-cell depletion”, 1st National Conference on human retroviruses and related infections Washington, DC (NIH) (1993)
    

16. -“Programmed cell death (apoptosis) and AIDS pathogenesis”. Biotechnology against AIDS 1994, Co-sponsored by CCE, NIAID, NIH and WHO. Florence, Italy (1994)
    

17. -“Programmed cell death (apoptosis) and AIDS”. The Biochemistry and Regulation of Programmed Cell Death, (J.A. Cidlowski, R.H. Horvitz, A. López Rivas, C. Martínez-A) Fundación Juan March Grant for Basic Research. Center for International Meetings on Biology, Madrid, Espagne. (1994)
    

18. -“Programmed cell death (apoptosis) and AIDS: A regulatory role for type1/type 2 cytokines?” (et co-chairman of the workshop on HIV infection: diagnosis and therapeutic aspects) 12th European Immunology Meeting, Barcelona, Spain (1994)
    

19. -“Programmed cell death (apoptosis) and AIDS”. 1rst French-Japanese Immunology Meeting, Pauillac, France (D. Mathis, C. Benoist) (1994)
    

20. -“Programmed cell death, Th1/Th2 cytokines and AIDS pathogenesis” Laboratory of Tumor Cell Biology Annual Meeting, (R.C. Gallo) Bethesda, MD, USA. (1994)
    

21. -“Accessory cells, TH1/TH2 cytokines, and programmed T cell death: relevance to AIDS pathogenesis”, IX Cent Gardes Meeting (M. Girard, L. Valette) (1994)
    

22. -”Programmed cell death, apoptosis and AIDS” Karolinska Institute Nobel Assembly Symposium: Frontiers in Medicine, Apoptosis-mechanisms, regulations and biomedical implications, Stockholm, Sweden (1995)
    

23. -“TH1/TH2 cytokines and the regulation of programmed T cell death in AIDS and parasite infection”. Keystone Symposium: Apoptosis, (J. Cohen, J. Cidlowski), Tamarron, Co, USA (1995)
    

24. -“Apoptosis in AIDS”. Royal Society of Edinburgh/Caledonian Research Foundation Conference: Pathology of Apoptosis: implications for mechanisms of disease, (A. Wyllie), Edinburg, UK (1995)
    

25. -“Apoptosis regulated by intercellular signalling in a unicellular organism: implications for the evolutionary origin of programmed cell death”. 1rst Gordon Conference on Cell Death, (R. Lockshin),New London, NH, USA (1995)
    

26. -“Apoptosis in a unicellulair eukaryote - Regulation of cell proliferation and differentiation as an evolutionary conserved role of programmed death” Cold Spring Harbor Laboratory Meeting: Programmed cell death (R. Horvitz, S. Korsmeyer, E. White), Cold Spring Harbor, NY, USA (1995);
    

27. -“Programmed cell death (apoptosis) of CD4 T cells in AIDS: involvement of Fas (CD95/Apo-1) and modulation by TH1/TH2 cytokines” Cold Spring Harbor Laboratory Meeting: Programmed cell death (R. Horvitz, S. Korsmeyer, E. White), Cold Spring Harbor, NY, USA (1995)
    

28. - “Apoptosis in host/pathogen interactions”. 2nd French-Japanese Immunology Meeting, (D. Mathis, C. Benoist, M. Taniguchi) Kyushu, Japon (1995)
    

29. - “Programmed cell death and AIDS pathogenesis”. 5th European Congress of Neuropathology, Paris (F. Gray) (1996)
    

30. - “Apoptosis and AIDS pathogenesis” Oxydative stress and redox regulation: cellular signaling, AIDS, cancer and other diseases. (L. Montagnier, R. Olivier) Paris, 1996
    

31. -“TH1/TH2 cytokines and Fas-mediated T-cell apoptosis in HIV infection” Institute of Human Virology 1996 Annual Meeting, (R.C. Gallo), Baltimore, MD, USA
    

32. -“Programmed cell death and AIDS pathogenesis” 3rd European Winter Conference in Immunology and Cell Biology, (JF Delfraissy, B. Dugas, D. Fradelizi), St-Sorlin d'Arves (1997)
    

33. -“On the origin and evolution of programmed cell death” Royal Netherlands Academy of Arts and Sciences : Academy Colloquium Pharmaceutical Intervention in Apoptotic Pathways, Amsterdam, Hollande (1997)
    

34. -“Programmed cell death: evolutionary origin, regulation and role in disease” (State of the Art Lecture) Institute of Human Virology 1997 Annual Meeting, (R.C. Gallo), Baltimore, MD, USA (1997)
    

35. -“Programmed cell death: evolutionary origin, regulation and role in disease” San Marino Conferences Scientific research at the dawning ot the 3rd millenium:Chronic viral diseases associated with immunodeficiency, cancer and neurological disorders (R.R. Redfield), San Marino (1997)
    

36. -“Programmed cell death: Lessons from phylogeny”. 2nd Gordon Conference on Cell Death, (M. Tenniswood, D.Green), New London, NH, USA (1997)
    

37. - “New insights into Programmed cell death” (State of the Art Lecture) Institute of Human Virology 1998 Annual Meeting, (R.C. Gallo), Baltimore, MD, USA (1998)
    

38. -“Apoptosis and AIDS” Karolinska Institute Nobel Conference: Pathogenesis and treatment of HIV infection, Stockholm, Sweden (1998)
    

39. -“Programmed cell death: evolutionary origin, regulation and role in disease” 6th DBMS/IBS International Workshop: Programmed cell death. Autrans, France (1999)
    

40. -"Programmed cell death and host-pathogen interactions". European School of Haematology-MD Anderson Cancer Center Symposium: Mechanisms of Cell Death and Disease: Advances in Therapeutic Intervention, Galway, Ireland (D. Jobin, T McDonnell) (2000)
    

41. -"Programmed cell death in early diverging unicellular eukaryotes: the kinetoplastid parasites". EMBO Workshop, Jacques Monod Conference: Cell death across kingdoms, (P.Golstein), Roscoff, France (2002)
    

42. -"Cell death and AIDS pathogenesis", 1rst Cell Death and Differentiation conference & 4th International SASS Foundation conference: Apoptosis in cancer and infection, Capri, Italie (2002)
    

43. -"On the origin, evolution and nature of programmed cell death" (Keynote Speaker), 5th molecular and cellular biology meeting: Apoptosis 2003 - From signalling pathways to therapeutic tools, Luxembourg
    

44. -“Looking for death at the core of life in the light of evolution” 2005 BSP Automn Symposium Meeting, Linnean Society : Programmed cell death and the protozoan parasite, Burlington House, London (2005).
    

45. -“Programmed Cell Death and Cell Signaling in Development and Disease”; (State of the Art Lecture), The Onassis Foundation Science Lecture Series/Foundation for Research and Technology Hellas (FORTH) 2005 Lectures in Biology: Programmed cell death, around Robert Horvitz (Nobel Prize laureate 2002), Heraklion, Creta Greece, (2005) and:
    

46. -“On the origin, evolution and nature of Programmed Cell Death” (State of the Art Lecture), The Onassis Foundation Science Lecture Series/Foundation for Research and Technology Hellas (FORTH) 2005 Lectures in Biology: Programmed cell death, around Robert Horvitz (Nobel Prize laureate 2002), Heraklion, Creta Greece, (2005)
    

47. -"On the origin, evolution and nature of programmed cell death" Metchnikoff’s Legacy in 2008, Institut Pasteur, Paris, symposium organisé pour le 100ème anniversaire du prix Nobel d’Elie Metchnikoff, 2008.
    

48. -"On the origin, evolution and nature of programmed cell death" Leopoldina symposium 'Evolution of Programmed Cell Death in Infection and Immunity'. Würzburg, Allemagne, 2009